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KMID : 0364819880260020101
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Korean Journal of Microbiology
1988 Volume.26 No. 2 p.101 ~ p.105
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3´ end of putative sequences of the packaging signal in Moloney-murine leukemia virus
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Park Jong-Sang
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Abstract
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1
6 M-MuLV mutants containing deletions around the putative packaging signal were constructed by using recombinant DNA technique and transfected into NIH/3T3 cell. 2 of 6 mutants pan not be packaged into virions even in the presence of the wild type helper virus. The boundary between the pac kagible and the non-packagible genome is located around Pvu I site, 421 nucleotide downstream from the 5´ end of M-MuLV genome. 10 base pair inverted repeat sequence (GAGUCCAAAA) which can make stem structure around Pvu I site could be the putative packaging signal.
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KEYWORD
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